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  • 本实验室主要研究项目包括:

      • 国家自然科学基金项目:组合应用NMR代谢组学和生物医学技术研究阿尔茨海默病的分子机制及其与糖尿病脑病的代谢关联

      • 国家自然科学基金面上项目:组合应用基于1H NMR的代谢组学和13C标记底物的13C NMR方法研究糖尿病脑病的代谢机制

      • 国家自然科学基金面上项目:严重低血糖新生大鼠脑内代谢物的高分辨魔角旋转磁共振波谱研究

      • 国家自然科学基金项目:骨髓间充质干细胞移植促进大鼠脑梗死CCD解除的代谢调控机制研究

      • 国家自然科学基金项目:道地中药温莪术治疗肾纤维化药效机制的代谢组学研究

      • 国家自然科学基金项目:新生大鼠高胆红素脑损伤的代谢调控网络与关键蛋白研究

      • 科技部973项目子课题:神经系统疾病的代谢组学研究

      • 浙江省医药卫生厅青年人才项目:用基于NMR的代谢组学技术进行肾癌的早期诊断和预后

      • 浙江省中医药管理局重点项目:温莪术治疗肾纤维化的动物代谢组学研究

      • 浙江省自然科学基金项目,影响糖尿病脑病的特异性蛋白及药物靶点的探索性研究

      • 浙江省自然科学基金项目,帕金森病对大鼠脑内代谢网络的影响及其分子机制研究

      • 浙江省自然科学基金项目,幕上单侧脑梗死后CCD侧脑组织的代谢调控机制研究

      • 浙江省自然科学基金项目:酸性成纤维细胞生长因子改构体调节帕金森病神经递质通路的分子机制研究

      • 浙江省自然科学基金项目:影响糖尿病脑病的特异性蛋白及药物靶点的探索性研究

    本实验室主要代表性论文包括:

    • Zhao LC, Dong MJ, Liao SX, et al, Identification of key metabolic changes in renal interstitial fibrosis rats using metabonomics and pharmacology. Scientific Reports, 2016. 6: 27194.

    • Zheng H, Ji J, Zhao L, et al, Prediction and diagnosis of renal cell carcinoma using nuclear magnetic resonance-based serum metabolomics and self-organizing maps. Oncotarget, 2016. DOI: 10.18632/oncotarget.10830.

    • Zheng H, Zheng YQ, Wang D, et al, Analysis of neuron-astrocyte metabolic cooperation in the brain of db/db mice with cognitive decline using 13C NMR spectroscopy. Journal of cerebral blood flow and metabolism, 2016. DOI: 10.1177/0271678X15626154.

    • Zheng YQ, Yang YJ, Dong BJ, et al, Metabonomic profiles delineate potential role of glutamate-glutamine cycle in db/db mice with diabetes-associated cognitive decline. Molecular Brain, 2016.9(1): 1-9.

    • Zheng H, Zhao LC, Xia HH, et al, NMR-Based Metabolomics Reveal a Recovery from Metabolic Changes in the Striatum of 6-OHDA-Induced Rats Treated with Basic Fibroblast Growth Factor. Molecular Neurobiology, 2015: 1-8.

    • Wang N, Zhao LC, Zheng YQ, et al, Alteration of interaction between astrocytes and neurons in different stages of diabetes: a nuclear magnetic resonance study using [1-13C]glucose and [2- 13C]acetate. Molecular Neurobiology, 2015, 51(3): 843-852.

    • Wei TT, Zhao LC, Jia JM, et al, Metabonomic analysis of potential biomarkers and drug targets involved in diabetic nephropathy mice. Scientific Reports, 2015, 5: 11998.

    • Hu WY, Cheng XJ, Ye XJ, et al, Ex vivo 1H nuclear magnetic resonance spectroscopy reveals systematic alterations in cerebral metabolites as the key pathogenetic mechanism of bilirubin encephalopathy. Molecular Brain, 2014, 7(1): 87.

    • Wang N, Zhao LC, ZhengYQ, et al, Alteration of Interaction Between Astrocytes and Neurons in Different Stages of Diabetes: a Nuclear Magnetic Resonance Study Using [1-13C] Glucose and [2-13C] Acetate., Molecular Neurobiology, 2014, 51(3): 843-852.

    • Zhao LC, Zhang HY, Yang YJ, et al, Serum Metabonomic Analysis of Protective Effects of Curcuma aromatica Oil on Renal Fibrosis Rats. Plos One, 2014, 9(9): e108678.

    • Diao CF, Zhao LC, Guan MM, et al, Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a 1H-NMR based metabonomic approach, MolecularBioSystems, 2014,10(3), 686-693.

    • Liu K, Ye XJ, Hu WY, et al, Neurochemical Changes in the Rat Occipital Cortex and Hippocampus after Repetitive and Profound Hypoglycemia During the Neonatal Period: An Ex Vivo 1H Magnetic Resonance Spectroscopy Study. Molecular Neurobiology, 2013, 48(3), 729-736.
    • Guan MM, Xie LY, Diao CF, et al, Systemic Perturbations of Key Metabolites in Diabetic Rats During the Evolution of Diabetes Studied by Urine Metabonomics. PLos One, 2013,8(4), e60409.

    • Gao HC, Zhu H, Song CY, Lin L, et al, Metabolic Changes Detected by Ex Vivo High Resolution 1H NMR Spectroscopy in the Striatum of 6-OHDA-Induced Parkinson's Rat. Molecular Neurobiology, 2013 Feb, 47(1):123-130.

    • Dong BJ, Jia JM, Hu WY, et al, Application of 1H NMR metabonomics in predicting renal function recoverability after the relief of obstructive uropathy in adult patients. Clinical Biochemistry, 2013 Mar, 46(4-5):346-353.
    • Zheng P, Gao HC, Qi ZG, et al, Peripheral metabolic abnormalities of lipids and amino acids implicated in increased risk of suicidal behavior in major depressive disorder. Metabolomics, 2013, DOI 10.1007/s11306-012-0474-9.
    • Zheng P, Gao HC, Li Q, et al, Plasma metabonomics as a novel diagnostic approach for major depressive disorder. Journal of Proteome Research, 2012 Mar, 11(3):1741-1748.
    • Huang RZ, Gao HC, Zhang L, et al, Born a disease virus infection perturbs energy metabolites and amino acids in cultured human oligoden droglia cells. PLos One, 2012 Sep, 7(9):e44665.
    • Zhang HY, Jia JM, Cheng J, et al, 1H NMR-based metabonomics study on serum of renal interstitial fibrosis rats induced by unilateral ureteral obstruction. Molecular BioSystems, 2012 Feb, 8(2):595-601.
    • Gao HC, Dong BJ, Jia JM, et al, Application of ex vivo 1H NMR metabonomics to the characterization and possible detection of renal cell carcinoma metastases. Journal of Cancer Research and Clinical Oncology, 2012 May, 138(5):753-761.
    • Zhao LC, Gao HC, Lian FL, et al, 1H NMR-based metabonomic analysis of metabolic profiling in diabetic nephropathy rats induced by streptozotocin. American Journal of Physiology-Renal Physiology, 2011 Apr, 300(4):F947–F956.
    • Xie LY, Song CY, Lou YY, et al, Studies on metabolic characteristics and pathological mechanisms of diabetic ulcers by 1H NMR-based metabonomics. Acta Chimica Sinica, 2011 Oct, 69(19):2265-2271.
    • Xie LY, Zhang ML, Dong BJ, et al, Improved refractory wound healing with administration of acidic fibroblast growth factor in diabetic rats. Diabetes Research and Clinical Practice, 2011 Sep. 93(3): 396-403.
    • Wu LM, Zhang ML, Lou YY, et al, Nuclear magnetic resonance studies on interactions of berberine and bovine serum albumin. Chinese J Anal Chem, 2011 Aug, 39(8):1223-1227.
    • Song ZY, Gao HC, Liu HY, et al, Metabolomics of rabbit aqueous humor after administration of glucocorticosteroid. Current Eye Research, 2011 Jun, 36(6):563-570.
    • Huang ZF, Lu MF, Zhu GH, et al, Acceleration of diabetic-wound healing with PEGylated rhaFGF in healing-impaired streptozocin diabetic rats. Wound Repair and Regeneration, 2011 Sep-Oct, 19(5):633-644.
    • Zhao LC, Zhang XD, Liao SX, et al, A metabonomic comparison of urinary changes in Zucker and GK rats. Journal of Biomedicine and Biotechnology, 2010 Oct, 2010:431894.
    • Zhao LC, Liu X, Xie LY, et al, 1H NMR-based metabonomic analysis of metabolic changes in streptozotocin-induced diabetic rats. Analytical Sciences, 2010 Dec, 26(12):1277-1282.
    • Liu X, Xiao Y, Gao HC, et al, Metabonomic study of aristolochic acid I-induced acute renal toxicity urine at female and male C57BL/6J mice based on 1H NMR. Chemical Journal of Chinese Universities-Chinese, 2010 Jun, 31(5):927-932.
    • Lin L, Song CY, Xie LY, et al, Electrochemical determination of xanthine and hypoxanthine in rat striatum with an acetylene black-dihexadecyl hydrogen phosphate composite film modified electrode by HPLC coupled with in vivo microdialysis. Microchimica Acta, 2010 Aug, 170(1-2):47-52.
    • Lin L, Gao HC, Lin D, et al, LC-ED with an Acetylene black-dihexadecyl hydrogen phosphate composite film-modified electrode for in vivo analysis of thiols in rat striatal microdialysate. Chromatographia, 2010 Sep, 72(5-6):447-452.
    • He HZ, Cong WT, Jiang CX, et al, A user-friendly alternative to formaldehyde-based DNA silver-staining method on polyacrylamide gels. Electrophoresis, 2010 Jul, 31(14):2416-2421.
    • Mao H, Wang H, Wang B, et al, Systemic Metabolic Changes of Traumatic Critically III Patients Revealed by an NMR-Based Metabonomic Approach. Journal of Proteome Research, 2009 Dec, 8(12):5423-5430.
    • Lu Q, Huang YH, Cong H, et al, Study on Metabonome in Human Serum with Hepatocellular Carcinoma or Liver Cirrhosis. Chinese Journal of Analytical Chemistry, 2009 Feb, 37(2): 194-198.
    • Guo C, Diao H, Lian YD, et al, Recombinant expression and characterization of an epididymis-specific antimicrobial peptide BIN1b/SPAG11E. Journal of Biotechnology, 2009 Jan, 139(1): 33-37.
    • Gao HC, Lu Q, Liu X, et al, Application of H-1 NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis. Cancer Science, 2009 Apr, 100(4):782-785.
    • Fu QS, Zhou CJ, Gao HC, et al, Structural Basis for Ubiquitin Recognition by a Novel Domain from Human Phospholipase A(2)-activating Protein. Journal of Biological Chemistry, 2009 Jul. 284(28): 19043-19052.
    • Zhou ZR, Gao HC, Zhou CJ, et al, Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights. Protein Science, 2008 Oct. 17(10):1805-1814.
    • Liu JF, Lin KJ, Guo CY, et al, Expression and purification of cysteine mutation isoforms of rat lipocalin-type prostaglandin D synthase for nuclear magnetic resonance study. Acta Biochimica Et Biophysica Sinica, 2008 Jun. 40(6): 489-496.
    • Li CX, Wang Y, Gao HC, et al, Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution H-1 magnetic resonance spectroscopy. Neurochemical Research, 2008 Nov. 33(11): 2342-2349.
    • Gao HC, Dong BJ, Liu X, et al, Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis. Analytica Chimica Acta, 2008 Aug, 624(2): 269-277.



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